郑永胜

郑永胜（副教授、博士生导师）

研究方向：药物化学、有机合成

电子邮箱：zhysh3811@163.com

电话：15172336102

ORCID：0000-0002-1019-5521

工作经历

2016/08-至今：中南民族大学药学院 讲师、副教授、博士生导师

2013/08-2015/07：美国中佛罗里大学化学系 研究助理/博士后

学习经历

2010/09-2013/07：中国科学院大学成都有机化学研究所 有机化学 博士

2007/09-2010/07：四川大学华西药学院 药物化学 硕士

2002/09-2006/07：西华大学 制药工程 本科

主讲课程

药物化学、药物化学实验。

科研项目

1.国家自然科学基金面上项目，82574290，2026/01-2029/12,主持。

2.国家自然科学基金面上项目，81973208，2020/01-2023/12，主持。

3.湖北省自然科学基金面上项目，Triazinanes反电子需求环加成反应高效合成类药四氢喹唑啉及其抗肿瘤活性研究，BZY18013，2019/01-2020/12，主持。

4.央高校基本科研业务费专项资金项目，CDK/HDAC双靶点抑制剂的设计合成及抗肿瘤活性研究，CZH26023，2026-2028，主持。

5.中央高校基本科研业务费专项资金项目，CZQ20011, 2020/1-2021/12,主持。

6.中央高校基本科研业务费专项资金项目，失B环天然产物Harringtonolide的骨架及类似物高效合成及抗肿瘤、感染活性研，CZQ17010，2017/01-2018/12,主持。

研究论文：

1.Luoqin Luo, Limei Gao, Dongqing He,Yuting Tian, Jikai Liu,*Yongsheng Zheng*, Cooperative Pd/Chiral Secondary Amine Enabled Diastereo- andEnantioselective [3+2] Cycloannulation: Synthesis ofPolysubstituted Cyclopentanes,Org. Lett.,2025,27, 1847−1852.

2.Hui Guo, Yuqi Tian, Xing Wu, Liang Tu, Jikai Liu*,Yongsheng Zheng*, Rong Huang*, Efficient assembly and anti-tumor evaluation of novel polycyclic [1,2-a]-fused indoles.Bioorganic Chemistry.2024,146, 107289.

3.Liang Tu, Sen Li, Li-Mei Gao,* Bo-Wei Tang,Yong-Sheng Zheng,*and Ji-Kai Liu*, Cooperative Rh/Achiral Phosphoric Acid-Enabled [3+3] Cycloannulation of Carbonyl Ylides with Quinone Monoimines: Synthesis of Benzofused Dioxabicyclo[3.2.1]octane Scaffolds.J. Org. Chem.2024,89, 9031−9042.

4.Xi Luo, Sen Li, Yuting Tian, Yuqi Tian, Limei Gao, Qiang Wang,*Yongsheng Zheng,*Atroposelective Construction of Naphthylpyrazoles by Chiral Phosphoric Acid Catalyzed Enantioselective Cross-Coupling of Pyrazoles with Naphthoquinone Esters,Eur. J. Org. Chem.2024,27(23), e202400254.

5.Yuting Tian, Ziyang Chen, Kexin Su,Yongsheng Zheng,*and Jikai Liua,*[2+2+1+1] Cycloaddition Reaction of 1,3,5-Triazinanes with Methylene Compounds: Approach to Hexahydropyrimidines.Adv. Synth. Catal.2023,365, 3909–3914.

6.Yuting Tian 1,†, Dongqing He 2,†, Limei Gao*, Yu Zou, Xiaoshuang Liu, Qiang Wang, Enxiang Liang* andYongsheng Zheng*, Regioselective Reaction of 2-Indolylmethanols with Enamides.Molecules,2023,28, 3341.

7.Qinglang Wei+, Liang Tu+, Sen Li,Yongsheng Zheng,*and Jikai Liu,*Palladium-Catalyzed [4+2] Cycloaddition of VinylBenzoxazinanones with 1,3-Indanedione: Approach toSpiro-Tetrahydroquinoline Scaffolds.Eur. J. Org. Chem.2023,26, e202300499.

8.Liang Tu, Limei Gao, Qiang Wang, Zhixing Cao, Rong Huang,Yongsheng Zheng,*and Jikai Liu*, Substrate-Switched Chemodivergent Pyrazole and Pyrazoline Synthesis: [3+2] Cycloaddition/Ring-Opening Rearrangement Reaction of Azadienes with Nitrile Imines.J. Org. Chem.2022,87, 3389−3401.

9.Limei . Gao+, Xiaomeng Wang+, Qinglang Wei, Kexin Su, Renhong Huang, Ju Guo,Yongsheng Zheng,*and Jikai Liu,* [3+3] Cycloadditions of Azomethine Ylides with Nitrile Imines for the Synthesis of 2,3,4,5-Tetrahydro-1,2,4-Triazine-5-Carboxylates,Eur. J. Org. Chem.2022, e202200768.

10.Limei Gao, Ruijie Shi, Yuting Tian, Xi Luo,Yongsheng Zheng, and Qiang Wang. Synthesis of Pyrazoles through [3+2] Cyclization of Nitrile Imines with Cinnamaldehydes Followed by Air Oxidation.ChemistrySelect2021,6, 12838–12842.

11.Ruijie Shi, Limei Gao, Weiji Chen, Yangqing Shi, Zhixing Cao,Yongsheng Zheng,* and Jikai Liu*. Formal [2+2+2] Cycloaddition Reaction of 1,3,5-Triazinanes with diethyl acetylene dicarboxylate: Approach to Tetrahydropyrimidines.Eur. J. Org. Chem.2021,44,5941–5945.

12.Liang Tu, Limei Gao, Xiaomeng Wang, Ruijie Shi, Rupei Ma, Junfei Li, Xiaoshuang Lan,Yongsheng Zheng,*and Jikai Liu,* [3+2] Cycloaddition of Nitrile Imines with Enamides: An Approach to Functionalized Pyrazolines and Pyrazoles.J. Org. Chem.2021,86(1),559−573.

13.Na Li, Liang Tu, Guiguang Cheng, Houling Sa, Zhenghui Li, Tao Feng,Yongsheng Zheng,*Jikai Liu.*Diastereoselective [3+3] cycloaddition reaction of 2-arylideneindan-1,3-diones with b-naphthols: Efficient assemble of immunosuppressive pentacyclic chromanes.Tetrahedron Letters.2020,61(10),151579-151587.

14.Y. S. Zheng,L. Tu, N. Li, R. Huang, T. Feng, H. Sun, Z. H. Li, J. K. Liu, Inverse-Electron-Demand [4+2]-Cycloaddition of 1,3,5-triazinanes: Facile Approaches to Tetrahydroquinazolines.Advanced. Synthesis & Catalyst.2019,361(1),44-48.

15.L. Tu, Z. H. Li, T. Feng, S. Y. Yu, R. Huang, J. Li, W. X. Wang,Y. S. Zheng,*J. K. Liu,*Access to Imidazolidines via 1,3-Dipolar Cycloadditions of 1,3,5-Triazinanes with Aziridine.The Journal of Organic Chemistry.2019,84(17), 11161-11169.

16.Y. S. Zheng, L. Tu, L. M. Gao, R. Huang, T. Feng, H. Sun, W. X. Wang, Z. H. Li, J. K. Liu. Accessing benzooxadiazepines via formal [4+3] cycloadditions of aza-o-quinone methides with nitrones.Organic & Biomolecular Chemistry,2018,16(15), 2639-2642.

17.Z.Y. Chu, N. Li, D. Liang, Z. H. Li,Y.S. Zheng,*J. K. Liu. Accessing Substituted Pyrrolidines via Formal [3+2] Cycloaddition of 1,3,5-Triazinanes and Donor-acceptor Cyclopropanes. Tetrahedron Letters.2018,59(8), 715-718.

18.Y. S. Zheng,J. Cleaveland, D, Richardson. Y. Yuan. “An Oganocatalysis Based Carbocyclic Spiroindoline Synthesis Enables Facile SAR Study at C-2 Position”.Organic. Letters.2015,17(17),4240–4243.

19.Yongsheng Zheng,Ebrahim H. Ghazvini Zadeh, Yu Yuan. One-Pot, Enantioselective Synthesis of 2,3-Dihydroazulen-6(1H)-one: A Concise Access to the Core Structure of Cephalotaxus Norditerpenes.European Journal of Organic Chemistry.2016,2016(12),2115–2119.

20.Yongsheng Zheng,Muqiong Liu, Yu Yuan. A very mild and selective method for O-benzoylation of hydroxamic acids.Tetrahedron Letters.2014.55 (31).4404-4406.

21.Y. S. Zheng, Z. Y. Xue, L. X. Liu, C. Shu, W. C. Yuan, X. M. Zhang. Highly enantioselective hydrosilylation of N-(1,2-diphenylethylidene)arylamines.Organic & Biomolecular Chemistry.2013,11(3),412-415.

本科生指导情况：

2018年 涂亮 校级优秀毕业论文（指导教师）

2018年 李娜国家级大学生创新训练项目（指导教师）

2020年 李娜 校级优秀毕业论文（指导教师）

2021年 撒厚灵 国家级大学生创新训练项目（指导教师）

2024年 陈紫阳 校级优秀毕业论文（指导老师）

2024年 赖欢 校级大学生创新训练项目 （指导老师）

2024年 李凡 校级大学生创新训练项目 （指导老师）

本科生以第一作者发表SCI论文情况

Na Li,（李娜，2016级本科生，第一作者）Liang Tu, Guiguang Cheng, Houling Sa, Zhenghui Li, Tao Feng, Yongsheng Zheng,* Jikai Liu.* Diastereoselective [3+3] cycloaddition reaction of 2-arylideneindan-1,3-diones with b-naphthols: Efficient assemble of immunosuppressive pentacyclic chromanes.Tetrahedron Letters.2020,61(10),151579-151587.

Yuting Tian†, Ziyang Chen†,(陈紫阳，2020级本科生并列第一作者) Kexin Su, Yongsheng Zheng,* and Jikai Liua,*[2+2+1+1] Cycloaddition Reaction of 1,3,5-Triazinanes with Methylene Compounds: Approach to Hexahydropyrimidines.Adv. Synth. Catal.2023,365, 3909–3914.